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L-9 and its receptor are predominantly involved in the pathogenesis of UC

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Nalleweg, N. ; Chiriac, M. T. ; Podstawa, E. ; Lehmann, Christian ; Rau, Tilmann T. ; Atreya, R. ; Krauss, Ekaterina ; Hundorfean, G. ; Fichtner-Feigl, Stefan ; et al.,
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 08 Sep 2017 12:30


Objective: Several pathogenic roles attributed over the past two decades to either T helper (Th)1 or Th2 cells are increasingly becoming associated with interleukin (IL)-17 and most recently IL-9 signalling. However, the implication of IL-9 in IBD has not been addressed so far. Design: We investigated the expression of IL-9 and IL-9R by using peripheral blood, biopsies and surgical samples. We ...


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