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Biochemical Characterization of the Human m6A-Methyltransferase Complex

Ringle, Sam (2017) Biochemical Characterization of the Human m6A-Methyltransferase Complex. PhD, Universität Regensburg.

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Date of publication of this fulltext: 20 Nov 2017 05:56

Abstract (English)

N6-methyladenosine (m6A) is one of the most prevalent RNA modifications present within messenger RNAs (mRNAs), with an average of 3-5 modified adenosines per transcript. The methyltransferase-like protein 3 (METTL3) and methyltransferase-like protein 14 (METTL14) have been reported to form a sta- ble dimeric complex that is responsible for the formation of m6A within mRNAs. The METTL14 subunit of ...

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Translation of the abstract (English)

N6-methyladenosine (m6A) is one of the most prevalent RNA modifications present within messenger RNAs (mRNAs), with an average of 3-5 modified adenosines per transcript. The methyltransferase-like protein 3 (METTL3) and methyltransferase-like protein 14 (METTL14) have been reported to form a sta- ble dimeric complex that is responsible for the formation of m6A within mRNAs. The METTL14 subunit of ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:20 November 2017
Referee:Prof. Dr. Gunter Meister and Prof. Dr. Joachim Griesenbeck and Prof. Dr. Klaus Grasser
Date of exam:15 November 2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Keywords:mRNA methylation; m6A; METTL3; METTL14; WTAP
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36344
Owner only: item control page

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