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Hyperosmotic stress enhances cytotoxicity of SMAC mimetics

URN to cite this document:
urn:nbn:de:bvb:355-epub-366210
DOI to cite this document:
10.5283/epub.36621
Bittner, Sebastian ; Knoll, Gertrud ; Ehrenschwender, Martin
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jan 2018 16:13



Abstract

Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical trials. In cancer cells, SMAC mimetic (SM)-mediated IAP depletion induces tumor ...

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