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Hyperosmotic stress enhances cytotoxicity of SMAC mimetics

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Bittner, Sebastian ; Knoll, Gertrud ; Ehrenschwender, Martin
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jan 2018 16:13


Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical trials. In cancer cells, SMAC mimetic (SM)-mediated IAP depletion induces tumor ...


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