Go to content
UR Home

Hyperosmotic stress enhances cytotoxicity of SMAC mimetics

Bittner, Sebastian, Knoll, Gertrud and Ehrenschwender, Martin (2017) Hyperosmotic stress enhances cytotoxicity of SMAC mimetics. Cell Death and Disease 2017 (8), e2967.

[img]
Preview
License: Creative Commons Attribution 4.0
PDF - Published Version
Download (1MB)
Date of publication of this fulltext: 26 Jan 2018 16:13

at publisher (via DOI)

Other URL: http://doi.org/10.1038/cddis.2017.355, https://www.nature.com/articles/cddis2017355

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical trials. In cancer cells, SMAC mimetic (SM)-mediated IAP depletion induces tumor ...

plus


Export bibliographical data



Item type:Article
Date:3 August 2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/cddis.2017.355DOI
Keywords:TUMOR-NECROSIS-FACTOR; ALPHA-DEPENDENT APOPTOSIS; KAPPA-B ACTIVATION; TNF-ALPHA; INDUCED NECROPTOSIS; BINDING PROTEIN; CELL-DEATH; L929 CELLS; CANCER; CIAP1;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36621
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons