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MMP-9 activity is increased by adiponectin in primary human hepatocytes but even negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

Wanninger, Josef ; Walter, Roland ; Bauer, Sabrina ; Eisinger, Kristina ; Schäffler, Andreas ; Dorn, Christoph ; Weiss, Thomas S. ; Hellerbrand, Claus ; Buechler, Christa



Abstract

Adiponectin protects from inflammation and fibrosis in metabolic liver disease. In the present study we analyzed whether this adipokine may directly affect the activity of matrix metalloproteinases (MMPs), central regulators of fibrinolysis, in hepatocytes. Global gene expression analysis indicated upregulation of MMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1) expression in primary ...

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