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Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study

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Broeker, A. ; Wicha, S. G. ; Dorn, Christoph ; Kratzer, Alexander Ludwig ; Schleibinger, M. ; Kees, Frieder ; Heininger, A. ; Kees, Martin G. ; Häberle, H.
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Date of publication of this fulltext: 08 Jan 2019 10:15


BackgroundTigecycline is a vital antibiotic treatment option for infections caused by multiresistant bacteria in the intensive care unit (ICU). Acute kidney injury (AKI) is a common complication in the ICU requiring continuous renal replacement therapy (CRRT), but pharmacokinetic data for tigecycline in patients receiving CRRT are lacking.MethodsEleven patients mainly with intra-abdominal ...


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