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Biomodulatory Treatment With Azacitidine, All-trans Retinoic Acid and Pioglitazone Induces Differentiation of Primary AML Blasts Into Neutrophil Like Cells Capable of ROS Production and Phagocytosis

Klobuch, Sebastian, Steinberg, Tim, Bruni, Emanuele, Mirbeth, Carina, Heilmeier, Bernhard, Ghibelli, Lina, Herr, Wolfgang, Reichle, Albrecht and Thomas, Simone (2018) Biomodulatory Treatment With Azacitidine, All-trans Retinoic Acid and Pioglitazone Induces Differentiation of Primary AML Blasts Into Neutrophil Like Cells Capable of ROS Production and Phagocytosis. Frontiers in Pharmacology 9 (1380), pp. 1-11.

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Date of publication of this fulltext: 29 Jan 2019 12:51

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Other URL: http://doi.org/10.3389/fphar.2018.01380, https://www.frontiersin.org/articles/10.3389/fphar.2018.01380/full


Abstract

Effective and tolerable salvage therapies for elderly patients with chemorefractory acute myeloid leukemia (AML) are limited and usually do not change the poor clinical outcome. We recently described in several chemorefractory elderly AML patients that a novel biomodulatory treatment regimen consisting of low-dose azacitidine (AZA) in combination with PPARγ agonist pioglitazone (PGZ) and ...

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Item type:Article
Date:27 November 2018
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fphar.2018.01380DOI
Keywords:azacitidine, all-trans retinoic acid, pioglitazone, acute myeloid leukemia, differentiation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38280
Owner only: item control page

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