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Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

Lee, Amanda J. ; Chen, Branson ; Chew, Marianne V. ; Barra, Nicole G. ; Shenouda, Mira M. ; Nham, Tina ; van Rooijen, Nico ; Jordana, Manel ; Mossman, Karen L. ; Schreiber, Robert D. ; Mack, Matthias ; Ashkar, Ali A.


The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in dendritic cells (DCs) or NK cells, is essential for NK cell function in response to a mucosal herpes simplex virus type 2 (HSV-2) infection. ...


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