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Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Brissot, Eolia ; Labopin, Myriam ; Stelljes, Matthias ; Ehninger, Gerhard ; Schwerdtfeger, Rainer ; Finke, Jürgen ; Kolb, Hans-Jochem ; Ganser, Arnold ; Schäfer-Eckart, Kerstin ; Zander, Axel R. ; Bunjes, Donald ; Mielke, Stephan ; Bethge, Wolfgang A. ; Milpied, Noël ; Kalhs, Peter ; Blau, Igor-Wolfgang ; Kröger, Nicolaus ; Vitek, Antonin ; Gramatzki, Martin ; Holler, Ernst ; Schmid, Christoph ; Esteve, Jordi ; Mohty, Mohamad ; Nagler, Arnon


Background: Primary refractory acute myeloid leukemia (PRF-AML) is associated with a dismal prognosis. Allogeneic stem cell transplantation (HSCT) in active disease is an alternative therapeutic strategy. The increased availability of unrelated donors together with the significant reduction in transplant-related mortality in recent years have opened the possibility for transplantation to a larger ...


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