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Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin

Oxlund, Christina, Kurt, Birgül, Schwarzensteiner, Ilona, Hansen, Mie R. , Stæhr, Mette , Svenningsen, Per , Jacobsen, Ib A., Hansen, Pernille B. , Thuesen, Anne D., Toft, Anja, Hinrichs, Gitte R., Bistrup, Claus and Jensen, Boye L. (2017) Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin. Pflügers Archiv - European Journal of Physiology 469 (5-6), pp. 655-667.

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Other URL: http://doi.org/10.1007/s00424-017-1938-6


Abstract

The proteinase prostasin is a candidate mediator for aldosterone-driven proteolytic activation of the epithelial sodium channel (ENaC). It was hypothesized that the aldosterone-mineralocorticoid receptor (MR) pathway stimulates prostasin abundance in kidney and urine. Prostasin was measured in plasma and urine from type 2 diabetic patients with resistant hypertension (n = 112) randomized to ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
10.1007/s00424-017-1938-6DOI
Keywords:EPITHELIAL SODIUM-CHANNEL; SERINE-PROTEASE ACTIVITY; COLLECTING DUCT CELLS; SURFACE EXPRESSION; BLOOD-PRESSURE; RAT-KIDNEY; ACTIVATION; PLASMIN; MARKER; IDENTIFICATION; Epithelial sodium channel; Proteolysis; Adrenal; Nephrotic syndrome; Aldosterone synthase
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38950
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