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Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines <i>in vitro</i> and AKT-driven hepatocarcinogenesis in mice

Cigliano, Antonio , Wang, Chunmei, Pilo, Maria G., Szydlowska, Marta , Brozzetti, Stefania , Latte, Gavinella, Pes, Giovanni M., Pascale, Rosa M., Seddaiu, Maria A., Vidili, Gianpaolo, Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Chen, Xin and Calvisi, Diego F. (2017) Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines <i>in vitro</i> and AKT-driven hepatocarcinogenesis in mice. Oncotarget 8 (33).

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Other URL: http://doi.org/10.18632/oncotarget.16927


Abstract

Upregulation of the heat shock transcription factor 1 (HSF1) has been described as a frequent event in many cancer types, but its oncogenic role in hepatocellular carcinoma (HCC) remains poorly delineated. In the present study, we assessed the function(s) of HSF1 in hepatocarcinogenesis via in vitro and in vivo approaches. In particular, we determined the importance of HSF1 on v-Akt murine ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.18632/oncotarget.16927DOI
Keywords:HEAT-SHOCK FACTOR-1; FATTY-ACID SYNTHASE; HEPATOCELLULAR-CARCINOMA; TRANSCRIPTION FACTOR-1; EXPRESSION; CANCER; CHAPERONES; PROMOTES; GLUCOSE; ROLES; hepatocellular carcinoma; HSF1; signaling pathways
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39286
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