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Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Zhang, Shanshan ; Song, Xinhua ; Cao, Dan ; Xu, Zhong ; Fan, Biao ; Che, Li ; Hu, Junjie ; Chen, Bin ; Dong, Mingjie ; Pilo, Maria G. ; Cigliano, Antonio ; Evert, Katja ; Ribback, Silvia ; Dombrowski, Frank ; Pascale, Rosa M. ; Cossu, Antonio ; Vidili, Gianpaolo ; Porcu, Alberto ; Simile, Maria M. ; Pes, Giovanni M. ; Giannelli, Gianluigi ; Gordan, John ; Wei, Lixin ; Evert, Matthias ; Cong, Wenming ; Calvisi, Diego F. ; Chen, Xin



Abstract

Background & Aims: Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. Methods: We established a novel ICC mouse model via hydrodynamic transfection of ...

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