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Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Zhang, Shanshan, Song, Xinhua, Cao, Dan, Xu, Zhong, Fan, Biao, Che, Li, Hu, Junjie, Chen, Bin, Dong, Mingjie, Pilo, Maria G., Cigliano, Antonio , Evert, Katja, Ribback, Silvia, Dombrowski, Frank, Pascale, Rosa M., Cossu, Antonio, Vidili, Gianpaolo, Porcu, Alberto, Simile, Maria M., Pes, Giovanni M., Giannelli, Gianluigi, Gordan, John, Wei, Lixin, Evert, Matthias, Cong, Wenming, Calvisi, Diego F. and Chen, Xin (2017) Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice. Journal of Hepatology 67 (6), pp. 1194-1203.

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Other URL: http://doi.org/10.1016/j.jhep.2017.07.006


Abstract

Background & Aims: Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. Methods: We established a novel ICC mouse model via hydrodynamic transfection of ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1016/j.jhep.2017.07.006DOI
Keywords:ANTITUMOR-ACTIVITY; KINASE INHIBITOR; CANCER; AKT; PATHWAY; THERAPY; MODELS; HEPATOCARCINOGENESIS; COACTIVATION; GENERATION; Intrahepatic cholangiocarcinoma; Dual mTOR inhibitor; Targeted therapy; Gemcitabine; Translational medicine; Mouse model; MLN0128
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39537
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