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Thrombin Generation by Valproate

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Mohrez, Morad
License: Creative Commons Attribution 4.0
PDF - Accepted Version
Date of publication of this fulltext: 15 Jul 2019 08:12

Abstract (English)

Pathological plasmatic thrombin generation can lead to many complications such as thrombotic/atherosclerotic diseases. The contact phase of blood coagulation can be triggered by low plasma concentrations of lipophilic or negatively charged groups. There are two main proteases that can start the whole intrinsic coagulation cascade: activated factor 12 (F12a) and kallikrein. ...


Translation of the abstract (German)

Pathologisch-erhöhte Aktivität von Thrombin in Blut kann zu Komplikationen führen, wie zum Beispiel zu thrombotischen/ atherosklerotischen Erkrankungen. Negativ geladene oder lipophile Substanzen können bereits in niedrigen Plasma-Konzen¬trationen die intrinsische Blutgerinnung (Starterenzyme: F12a und/oder Kallikrein) aktivieren. Es besteht eine große individuelle Variabilität bezüglich des ...


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