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Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis

Heimer, Sina, Knoll, Gertrud, Schulze-Osthoff, Klaus and Ehrenschwender, Martin (2019) Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis. Cell Death & Disease 10 (8), pp. 1-13.

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Date of publication of this fulltext: 25 Jul 2019 08:12

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Other URL: http://doi.org/10.1038/s41419-019-1790-z


Abstract

Most antineoplastic chemotherapies eliminate cancer cells through activation of the mitochondria-controlled intrinsic apoptotic pathway. Therein, BAX, BAK, and/or BOK function as the essential pore-forming executioners of mitochondrial outer membrane permeabilization (MOMP). The activation threshold of BAX and BAK also correlates inversely with the required strength of an apoptotic stimulus to ...

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Item type:Article
Date:19 July 2019
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41419-019-1790-zDOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40572
Owner only: item control page

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