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Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes

Wester, Michael, Heller, Anton, Gruber, Michael , Maier, Lars S., Schach, Christian and Wagner, Stefan (2019) Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes. PLOS ONE 14 (9), e0222341.

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Date of publication of this fulltext: 11 Oct 2019 09:21

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Other URL: http://doi.org/10.1371/journal.pone.0222341


Abstract

Aims Glucocorticoid (GC) stimulation has been shown to increase cardiac contractility by elevated intracellular [Ca] but the sources for Ca entry are unclear. This study aims to determine the role of store-operated Ca entry (SOCE) for GC-mediated inotropy. Methods and results Dexamethasone (Dex) pretreatment significantly increased cardiac contractile force ex vivo in Langendorff-perfused ...

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Item type:Article
Date:9 September 2019
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0222341DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40814
Owner only: item control page

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