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Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes

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Wester, Michael ; Heller, Anton ; Gruber, Michael ; Maier, Lars S. ; Schach, Christian ; Wagner, Stefan
Date of publication of this fulltext: 11 Oct 2019 09:21


Aims Glucocorticoid (GC) stimulation has been shown to increase cardiac contractility by elevated intracellular [Ca] but the sources for Ca entry are unclear. This study aims to determine the role of store-operated Ca entry (SOCE) for GC-mediated inotropy. Methods and results Dexamethasone (Dex) pretreatment significantly increased cardiac contractile force ex vivo in Langendorff-perfused ...


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