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Mismatch Repair Proteins hMLH1 and hMSH2 Are Differently Expressed in the Three Main Subtypes of Sporadic Renal Cell Carcinoma

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Stoehr, Christine ; Burger, Maximilian ; Stoehr, Robert ; Bertz, Simone ; Ruemmele, Petra ; Hofstädter, Ferdinand ; Denzinger, Stefan ; Wieland, Wolf Ferdinand ; Hartmann, Arndt ; Walter, Bernhard
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Date of publication of this fulltext: 23 Oct 2019 12:53


Objectives: We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH1) and human MutS homologue 2 (hMSH2) in the main subtypes of renal cell carcinoma (RCC). Methods: Expression of MMR proteins hMLH1 and hMSH2 were investigated in 166 RCC tumors, containing the main subtypes by immunohistochemistry. Furthermore, each tumor was screened for microsatellite ...


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