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Control of Ion Transport by Tmem16a Expressed in Murine Intestine

URN to cite this document:
urn:nbn:de:bvb:355-epub-411038
Kunzelmann, Karl ; Centeio, Raquel ; Wanitchakool, Podchanart ; Cabrita, Inês ; Benedetto, Roberta ; Saha, Tultul ; Hoque, Kazi Mirajul ; Schreiber, Rainer
Date of publication of this fulltext: 29 Nov 2019 11:58


Abstract

Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not exclusively, as a basolaterally located Cl– channel that controls basolateral Ca2+ signaling, and thus activation of basolateral Ca2+ dependent Sk4 K+ ...

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