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Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition

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Dietl, Alexander ; Winkel, Ingrid ; Pietrzyk, Gabriela ; Paulus, Michael ; Bruckmann, Astrid ; Schröder, Josef A. ; Sossalla, Samuel ; Luchner, Andreas ; Maier, Lars S. ; Birner, Christoph
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Jan 2020 09:40


Background Heart failure induced cachexia is highly prevalent. Insights into disease progression are lacking. Methods Early state of left ventricular dysfunction (ELVD) and symptomatic systolic heart failure (HF) were both induced in rabbits by tachypacing. Tissue of limb muscle (LM) was subjected to histologic assessment. For unbiased characterisation of early and late myopathy, a proteomic ...


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