Correlative study on impaired prostaglandin E2 regulation in EAT and maladaptive cardiac remodeling via EPAC2 and ST2 signaling in overweight CVD subjects

URN to cite this document:: urn:nbn:de:bvb:355-epub-415013
DOI to cite this document:: 10.5283/epub.41501

Vianello, E. ; Dozio, E. ; Bandera, F. ; Froldi, M. ; Micaglio, E. ; Lamont, J. ; Tacchini, L. ; Schmitz, Gerd ;

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Date of publication of this fulltext: 05 Feb 2020 14:30

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Abstract

There is recent evidence that the dysfunctional responses of a peculiar visceral fat deposit known as epicardial adipose tissue (EAT) can directly promote cardiac enlargement in the case of obesity. Here, we observed a newer molecular pattern associated with LV dysfunction mediated by prostaglandin E2 (PGE(2)) deregulation in EAT in a cardiovascular disease (CVD) population. A series of 33 ...