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Adverse event grading following CTCAE v3.0 underestimates hypertensive side effects in patients with glioma treated with Bevacizumab

Bumes, Elisabeth ; Rzonsa, Sarah ; Hutterer, Markus ; Proescholdt, Martin ; Bogdahn, Ulrich ; Riemenschneider, Markus J. ; Uhl, Martin ; Wendl, Christina ; Hau, Peter



Abstract

Anti-VEGF therapy with Bevacizumab (BEV) is widely used in cases of relapsed high-grade glioma (HGG). Arterial hypertension is a known side effect of anti-VEGF therapy. 42 Patients with relapsed HGG were treated with BEV 10 mg/kg on days 1 and 15 of 28-day cycles in addition to treatment with 40 mg TMZ daily until disease progression, based on magnetic resonance imaging and/or worsening of ...

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