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Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles

Bosch, Oliver J. ; Dabrowska, Joanna ; Modi, Meera E. ; Johnson, Zachary V. ; Keebaugh, Alaine C. ; Barrett, Catherine E. ; Ahern, Todd H. ; Guo, JiDong ; Grinevich, Valery ; Rainnie, Donald G. ; Neumann, Inga D. ; Young, Larry J.



Abstract

Loss of a partner can have severe effects on mental health. Here we explore the neural mechanisms underlying increased passive stress-coping, indicative of depressive-like behavior, following the loss of the female partner in the monogamous male prairie vole. We demonstrate that corticotropin-releasing factor receptor 2 (CRFR2) in the nucleus accumbens shell mediates social loss-induced passive ...

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