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Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma

Geissler, Edward K. ; Schnitzbauer, Andreas A. ; Zülke, Carl ; Lamby, Philipp E. ; Proneth, Andrea ; Duvoux, Christophe ; Burra, Patrizia ; Jauch, Karl-Walter ; Rentsch, Markus ; Ganten, Tom M. ; Schmidt, Jan ; Settmacher, Utz ; Heise, Michael ; Rossi, Giorgio ; Cillo, Umberto ; Kneteman, Norman ; Adam, René ; van Hoek, Bart ; Bachellier, Philippe ; Wolf, Philippe ; Rostaing, Lionel ; Bechstein, Wolf O. ; Rizell, Magnus ; Powell, James ; Hidalgo, Ernest ; Gugenheim, Jean ; Wolters, Heiner ; Brockmann, Jens ; Roy, André ; Mutzbauer, Ingrid ; Schlitt, Angela ; Beckebaum, Susanne ; Graeb, Christian ; Nadalin, Silvio ; Valente, Umberto ; Turrión, Victor Sánchez ; Jamieson, Neville ; Scholz, Tim ; Colledan, Michele ; Fändrich, Fred ; Becker, Thomas ; Söderdahl, Gunnar ; Chazouillères, Olivier ; Mäkisalo, Heikki ; Pageaux, Georges-Philippe ; Steininger, Rudolf ; Soliman, Thomas ; de Jong, Koert P. ; Pirenne, Jacques ; Margreiter, Raimund ; Pratschke, Johann ; Pinna, Antonio D. ; Hauss, Johann ; Schreiber, Stefan ; Strasser, Simone ; Klempnauer, Jürgen ; Troisi, Roberto I. ; Bhoori, Sherrie ; Lerut, Jan ; Bilbao, Itxarone ; Klein, Christian G. ; Königsrainer, Alfred ; Mirza, Darius F. ; Otto, Gerd ; Mazzaferro, Vincenzo ; Neuhaus, Peter ; Schlitt, Hans J.



Abstract

Background We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC). Methods In a prospective-randomized open-label international trial, 525 LTx recipients with HCC initially receiving mammalian target of rapamycin inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation ...

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