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Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia

Krug, U ; Berdel, W E ; Gale, R P ; Haferlach, C ; Schnittger, S ; Müller-Tidow, C ; Braess, J ; Spiekermann, K ; Staib, P ; Beelen, D ; Serve, H ; Schliemann, C ; Stelljes, M ; Balleisen, L ; Maschmeyer, G ; Grüneisen, A ; Eimermacher, H ; Giagounidis, A ; Rasche, H ; Hehlmann, R ; Lengfelder, E ; Thiel, E ; Reichle, A ; Aul, C ; Ludwig, W-D ; Kern, W ; Haferlach, T ; Köpcke, W ; Görlich, D ; Sauerland, M C ; Heinecke, A ; Wörmann, B J ; Hiddemann, W ; Büchner, T



Abstract

We randomized 3375 adults with newly diagnosed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome to test whether increasingly intensive chemotherapies assigned at study-entry and analyzed on an intent-to-treat basis improved outcomes. In total, 1529 subjects <60 years were randomized to receive: (1) a first course of induction therapy with high-dose cytarabine and mitoxantrone ...

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