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Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice

Hu, Zhongshuang ; Murakami, Taisuke ; Suzuki, Kaori ; Tamura, Hiroshi ; Reich, Johannes ; Kuwahara-Arai, Kyoko ; Iba, Toshiaki ; Nagaoka, Isao


LL-37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL-37 can modulate various inflammatory reactions. We previously revealed that LL-37 suppresses the LPS/ATP-induced pyroptosis of macrophages in vitro by both neutralizing the action of LPS and inhibiting the response of P2X(7) (a nucleotide ...


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