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An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

Knies, Diana ; Klobuch, Sebastian ; Xue, Shao-An ; Birtel, Matthias ; Echchannaoui, Hakim ; Yildiz, Oezlem ; Omokoko, Tana ; Guillaume, Philippe ; Romero, Pedro ; Stauss, Hans ; Sahin, Ugur ; Herr, Wolfgang ; Theobald, Matthias ; Thomas, Simone ; Voss, Ralf-Holger



Abstract

Immunotherapy of cancer envisions the adoptive transfer of T-cells genetically engineered with tumor-specific heterodimeric alpha/beta T-cell receptors (TCR alpha/beta). However, potential mispairing of introduced TCR alpha/beta-chains with endogenous beta/alpha-ones may evoke unpredictable autoimmune reactivities. A novel single chain (sc) TCR format relies on the fusion of the V alpha-Linker-V ...

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