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Species- and concentration-dependent differences of acetyl- and butyrylcholinesterase sensitivity to physostigmine and neostigmine

Bitzinger, Diane I. ; Gruber, Michael ; Tümmler, Simon ; Michels, Bernhard ; Bundscherer, Anika ; Hopf, Susanne ; Trabold, Benedikt ; Graf, Bernhard M. ; Zausig, York A.



Abstract

Previous and more recent studies show that cholinesterase inhibitors (ChE-Is) are an important possibility for therapeutic intervention in Alzheimer's Disease, sepsis and other inflammatory syndromes. ChE-Is maintain high levels of acetylcholine (ACh) determining beneficial effects on the disease process. Despite numerous efforts to identify the appropriate choice of agents and dose of ChE-Is, a ...

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