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Erythropoietin production by PDGFR-β+ cells

Gerl, Katharina ; Nolan, Karen A. ; Karger, Christian ; Fuchs, Michaela ; Wenger, Roland H. ; Stolt, Claus C. ; Willam, Carsten ; Kurtz, Armin ; Kurt, Birgül



Abstract

PDGFR-beta-expressing cells of the kidneys are considered as a relevant site of erythropoietin (EPO) production. The origin of these cells, their contribution to renal EPO production, and if PDGFR-beta-positive cells in other organs are also capable to express EPO are less clear. We addressed these questions in mice, in which hypoxia-inducible transcription factors were stabilized in ...

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