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Piezo1-dependent regulation of urinary osmolarity

Martins, Joana Raquel ; Penton, David ; Peyronnet, Rémi ; Arhatte, Malika ; Moro, Céline ; Picard, Nicolas ; Kurt, Birgül ; Patel, Amanda ; Honoré, Eric ; Demolombe, Sophie



Abstract

The collecting duct (CD) is the final segment of the kidney involved in the fine regulation of osmotic and ionic balance. During dehydration, arginine vasopressin (AVP) stimulates the expression and trafficking of aquaporin 2 (AQP2) to the apical membrane of CD principal cells, thereby allowing water reabsorption from the primary urine. Conversely, when the secretion of AVP is lowered, as for ...

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