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α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy

Ettle, Benjamin ; Kerman, Bilal E. ; Valera, Elvira ; Gillmann, Clarissa ; Schlachetzki, Johannes C. M. ; Reiprich, Simone ; Büttner, Christian ; Ekici, Arif B. ; Reis, André ; Wegner, Michael ; Bäuerle, Tobias ; Riemenschneider, Markus J. ; Masliah, Eliezer ; Gage, Fred H. ; Winkler, Jürgen



Abstract

Multiple system atrophy (MSA) is a rare atypical parkinsonian disorder characterized by a rapidly progressing clinical course and at present without any efficient therapy. Neuropathologically, myelin loss and neurodegeneration are associated with alpha-synuclein accumulation in oligodendrocytes, but underlying pathomechanisms are poorly understood. Here, we analyzed the impact of oligodendrocytic ...

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