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NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

Knoll, Gertrud ; Riffelsberger, Petra ; Raats, Danielle ; Kranenburg, Onno ; Ehrenschwender, Martin
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Date of publication of this fulltext: 12 May 2020 12:54


Abstract

A sophisticated network of BCL-2 family proteins regulates the mitochondria-associated (intrinsic) apoptosis pathway. Antiapoptotic members such as BCL-XL or MCL-1 safeguard the outer mitochondrial membrane and prevent accidental cell death in a functionally redundant and/or compensatory manner. However, BCL-XL/MCL-1-mediated “dual apoptosis protection” also impairs response of cancer cells to ...

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