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Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy

Tafelmeier, Maria ; Baessler, Andrea ; Wagner, Stefan ; Unsoeld, Bernhard ; Preveden, Andrej ; Barlocco, Fausto ; Tomberli, Alessia ; Popovic, Dejana ; Brennan, Paul ; MacGowan, Guy A. ; Ristic, Arsen ; Velicki, Lazar ; Olivotto, Iacopo ; Jakovljevic, Djordje G. ; Maier, Lars S.
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Date of publication of this fulltext: 18 Jun 2020 15:00


Abstract

Background Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease with a broad spectrum of disease severity. HCM ranges from a benign course to a progressive disorder characterized by angina, heart failure, malignant arrhythmia, syncope, or sudden cardiac death. So far, no medical treatment has reliably shown to halt or reverse progression of HCM or to alleviate its ...

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