DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability

URN to cite this document:: urn:nbn:de:bvb:355-epub-440362
DOI to cite this document:: 10.5283/epub.44036

Kramm, Kevin ; Schröder, Tim ; Gouge, Jerome

; Vera, Andrés Manuel

; Gupta, Kapil

; Heiss, Florian B.

; Liedl, Tim

; Engel, Christoph ; Berger, Imre

; Vannini, Alessandro

; Tinnefeld, Philip ; Grohmann, Dina

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Date of publication of this fulltext: 02 Nov 2020 11:29

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Abstract

The TATA-binding protein (TBP) and a transcription factor (TF) IIB-like factor are important constituents of all eukaryotic initiation complexes. The reason for the emergence and strict requirement of the additional initiation factor Bdp1 in the RNA polymerase (RNAP) III system, however, remained elusive. A poorly studied aspect in this context is the effect of DNA strain arising from DNA ...