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Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses

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Wagner, Ralf ; Hauser, Alexandra ; Carnell, George ; Held, Kathrin ; Sulbaran, Guidenn ; Tischbierek, Nadine ; Rogers, Lisa ; Pollakis, Georgios ; Tonks, Paul ; Hoelscher, Michael ; Ding, Song ; Sanders, Rogier W. ; Geldmacher, Christof ; Sattentau, Quentin ; Weissenhorn, Winfried ; Heeney, Jonathan L. ; Peterhoff, David
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 11 Nov 2021 11:52


Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn, will most likely be a prerequisite for the development of an efficacious preventive vaccine. Here, we systematically analyzed how the stepwise stabilization of a clade C ...


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