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The Minimum Detectable Difference (MDD) Concept for Establishing Trust in Nonsignificant Results: A Critical Review

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Mair, Magdalena M. ; Kattwinkel, Mira ; Jakoby, Oliver ; Hartig, Florian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Jan 2021 11:16

This publication is part of the DEAL contract with Wiley.


Current regulatory guidelines for pesticide risk assessment recommend that nonsignificant results should be complemented by the minimum detectable difference (MDD), a statistical indicator that is used to decide whether the experiment could have detected biologically relevant effects. We review the statistical theory of the MDD and perform simulations to understand its properties and error rates. ...


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