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Identification and In-Depth Analysis of the Novel FGFR2-NDC80 Fusion in a Cholangiocarcinoma Patient: Implication for Therapy

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Scheiter, Alexander ; Keil, Felix ; Lüke, Florian ; Grosse, Jirka ; Verloh, Niklas ; Opitz, Sabine ; Schlosser, Sophie ; Kandulski, Arne ; Pukrop, Tobias ; Dietmaier, Wolfgang ; Evert, Matthias ; Calvisi, Diego F. ; Utpatel, Kirsten
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Mar 2021 14:11


Fibroblast growth factor receptor 2 (FGFR2) fusions have emerged as a new therapeutic target for cholangiocarcinoma in clinical practice following the United States Food and Drug Administration (FDA) approval of Pemigatinib in May 2020. FGFR2 fusions can result in a ligand-independent constitutive activation of FGFR2 signaling with a downstream activation of multiple pathways, including the ...


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