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TRUCKS, the fourth generation CAR T cells: current developments and clinical translation

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Chmielewski, Markus ; Abken, Hinrich
Date of publication of this fulltext: 01 Feb 2021 07:36

This publication is part of the DEAL contract with Wiley.


The overriding goal of adoptive cell therapy with chimeric antigen receptor (CAR) redirected T cells in oncology is to eliminate cancer cells from infiltrated tissues. Clinical trials document that this form of immunotherapy can induce lasting remissions of hematologic malignancies; however, the successes could not yet be transferred to the treatment of solid tumors. In this situation, modulating ...


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