Interaction of Bestrophin-1 and Ca2+ Channel β-Subunits: Identification of New Binding Domains on the Bestrophin-1 C-Terminus

URN to cite this document:: urn:nbn:de:bvb:355-epub-451705
DOI to cite this document:: 10.5283/epub.45170

Launikonis, Bradley Steven ; Milenkovic, Vladimir M.

; Krejcova, Sarka ; Reichhart, Nadine ; Wagner, Andrea ; Strauß, Olaf

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Date of publication of this fulltext: 08 Mar 2021 08:18

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Abstract

Bestrophin-1 modulates currents through voltage-dependent L-type Ca2+ channels by physically interacting with the β-subunits of Ca2+ channels. The main function of β-subunits is to regulate the number of pore-forming CaV-subunits in the cell membrane and modulate Ca2+ channel currents. To understand the influence of full-length bestrophin-1 on β-subunit function, we studied binding and ...