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Epistatic interactions of genetic loci associated with age-related macular degeneration

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DOI to cite this document:
Weber, Bernhard H. F. ; Kiel, Christina ; Nebauer, Christoph A. ; Strunz, Tobias ; Stelzl, Simon
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Feb 2022 15:24


The currently largest genome-wide association study (GWAS) for age-related macular degeneration (AMD) defines disease association with genome-wide significance for 52 independent common and rare genetic variants across 34 chromosomal loci. Overall, these loci contain over 7200 variants and are enriched for genes with functions indicating several shared cellular processes. Still, the precise ...


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