Propofol Ameliorates Exaggerated Human Neutrophil Activation in a LPS Sepsis Model

URN to cite this document:: urn:nbn:de:bvb:355-epub-460477
DOI to cite this document:: 10.5283/epub.46047

Bredthauer, Andre ; Geiger, Angela ; Gruber, Michael

; Pfaehler, Sophie-Marie ; Petermichl, Walter ; Bitzinger, Diane ; Metterlein, Thomas ; Seyfried, Timo

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Date of publication of this fulltext: 11 Nov 2021 11:49

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Abstract

Background: Sepsis is a leading cause of morbidity and mortality worldwide. Many patients suffering from sepsis are treated on intensive care units and many of them require mechanical ventilation under sedation or general anesthesia. Propofol, a drug used for these purposes, is known to interact with polymorphonuclear granulocytes (PMNs). Therefore, the aim of this study was to investigate the ...