Insights Into the Micelle-Induced β-Hairpin-to-α-Helix Transition of a LytA-Derived Peptide by Photo-CIDNP Spectroscopy

URN to cite this document:: urn:nbn:de:bvb:355-epub-462710
DOI to cite this document:: 10.5283/epub.46271

Gomez, M. V.

; Ruiz-Castañeda, M. ; Nitschke, Philipp

; Gschwind, Ruth Maria

; Jiménez, M. A.

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Date of publication of this fulltext: 02 Jul 2021 10:20

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Abstract

A choline-binding module from pneumococcal LytA autolysin, LytA(239-252,) was reported to have a highly stable nativelike beta-hairpin in aqueous solution, which turns into a stable amphipathic alpha-helix in the presence of micelles. Here, we aim to obtain insights into this DPC-micelle triggered beta-hairpin-to-alpha-helix conformational transition using photo-CIDNP NMR experiments. Our results ...