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The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites

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Mendes, Karina ; Schmidhofer, Sandra ; Minderjahn, Julia ; Glatz, Dagmar ; Kiesewetter, Claudia ; Raithel, Johanna ; Wimmer, Julia ; Gebhard, Claudia ; Rehli, Michael
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Date of publication of this fulltext: 15 Jul 2021 17:57


The differentiation of human blood monocytes (MO), the post-mitotic precursors of macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of DNA methylation, but the extent, consequences and mechanisms of DNA methylation changes remain unclear. Here, we profile and compare epigenetic landscapes during IL-4/GM-CSF-driven MO differentiation across the genome and detect ...


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