; Schäfer, Niklas ; Steinbach, Joachim P. ; Weyerbrock, Astrid ; Hau, Peter
; Goldbrunner, Roland ; Niessen, Michael ; Mack, Frederic ; Stuplich, Moritz ; Tzaridis, Theophilos ; Bähr, Oliver ; Kortmann, Rolf-Dieter ; Schlegel, Uwe ; Schmidt-Graf, Friederike ; Rohde, Veit ; Braun, Christian ; Hänel, Mathias ; Sabel, Michael ; Gerlach, Rüdiger ; Krex, Dietmar ; Belka, Claus ; Vatter, Hartmut ; Proescholdt, Martin ; Herrlinger, Ulrich ; Glas, Martin | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Journal of Cancer Research and Clinical Oncology | ||||
| Publisher: | Springer | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 144 | ||||
| Number of Issue or Book Chapter: | 8 | ||||
| Page Range: | pp. 1581-1589 | ||||
| Date: | 2018 | ||||
| Institutions: | Medicine > Lehrstuhl für Neurologie | ||||
| Identification Number: |
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| Keywords: | NEWLY-DIAGNOSED GLIOBLASTOMA; BEVACIZUMAB PLUS IRINOTECAN; RECURRENT GLIOBLASTOMA; ANTIANGIOGENIC THERAPY; MALIGNANT GLIOMAS; FACTOR RECEPTOR-2; PHASE-III; IN-VIVO; PROGRESSION; SURVIVAL; Bevacizumab; Newly diagnosed MGMT-non-methylated glioblastoma; MRI tumor growth patterns; Progression patterns | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 46963 |
Abstract
We evaluated patterns of tumor growth in patients with newly diagnosed MGMT-non-methylated glioblastoma who were assigned to undergo radiotherapy in conjunction with bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ) within the randomized phase II GLARIUS trial. In 142 patients (94 BEV/IRI, 48 TMZ), we reviewed magnetic resonance imaging scans at baseline and first tumor recurrence. ...

Abstract
We evaluated patterns of tumor growth in patients with newly diagnosed MGMT-non-methylated glioblastoma who were assigned to undergo radiotherapy in conjunction with bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ) within the randomized phase II GLARIUS trial. In 142 patients (94 BEV/IRI, 48 TMZ), we reviewed magnetic resonance imaging scans at baseline and first tumor recurrence. Based on contrast-enhanced T1-weighted and fluid-attenuated inversion recovery images, we assessed tumor growth patterns and tumor invasiveness. Tumor growth patterns were classified as either multifocal or local at baseline and recurrence; at first recurrence, we additionally assessed whether distant lesions appeared. Invasiveness was determined as either diffuse or non-diffuse. Associations with treatment arms were calculated using Fisher's exact test. At baseline, 115 of 142 evaluable patients (81%) had a locally confined tumor. Between treatment arms, there was no significant difference in the fraction of tumors that changed from an initially local tumor growth pattern to a multifocal pattern (12 and 13%, p = 0.55). Distant lesions appeared in 17% (BEV/IRI) and 13% (TMZ) of patients (p = 0.69). 15% of patients in the BEV/IRI arm and 8% in the TMZ arm developed a diffuse growth pattern from an initially non-diffuse pattern (p = 0.42). The tumor growth and invasiveness patterns do not differ between BEV/IRI and TMZ-treated MGMT-non-methylated glioblastoma patients in the GLARIUS trial. BEV/IRI was not associated with an increased rate of multifocal, distant, or highly invasive tumors at the time of recurrence.
Metadata last modified: 28 Jul 2021 17:09
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