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Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells

Barro-Soria, Rene ; Caicedo, Alejandro ; Jägle, Herbert ; Merkel, Laura ; Zhao, Na ; Knop, Gabriel ; Gierke, Kaspar ; Dannullis, Andrea ; Castrop, Hayo ; Brandstätter, Johann Helmut ; Kirchhoff, Frank ; Feigenspan, Andreas ; Strauß, Olaf


Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In ...


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