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The human tissue-resident CCR5+T cell compartment maintains protective and functional properties during inflammation

Woodward Davis, Amanda S. ; Roozen, Hayley N. ; Dufort, Matthew J. ; DeBerg, Hannah A. ; Delaney, Martha A. ; Mair, Florian ; Erickson, Jami R. ; Slichter, Chloe K. ; Berkson, Julia D. ; Klock, Alexis M. ; Mack, Matthias ; Lwo, Yu ; Ko, Alexander ; Brand, Rhonda M. ; McGowan, Ian ; Linsley, Peter S. ; Dixon, Douglas R. ; Prlic, Martin



Zusammenfassung

CCR5 is thought to play a central role in orchestrating migration of cells in response to inflammation. CCR5 antagonists can reduce inflammatory disease processes, which has led to an increased interest in using CCR5 antagonists in a wide range of inflammation-driven diseases. Paradoxically, these antagonists appear to function without negatively affecting host immunity at barrier sites. We ...

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