; Schäfer, Niklas ; Steinbach, Joachim P. ; Weyerbrock, Astrid ; Hau, Peter ; Goldbrunner, Roland ; Galldiks, Norbert
; Weller, Johannes
; Mack, Frederic ; Tzaridis, Theophilos ; Bähr, Oliver ; Seidel, Clemens ; Schlegel, Uwe ; Schmidt-Graf, Friederike ; Rohde, Veit ; Borchers, Christian ; Tabatabai, Ghazaleh
; Hänel, Mathias ; Sabel, Michael ; Gerlach, Rüdiger ; Krex, Dietmar ; Belka, Claus ; Vatter, Hartmut ; Proescholdt, Martin ; Glas, Martin ; Herrlinger, Ulrich | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Journal of Neuro-Oncology | ||||
| Publisher: | Springer | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 144 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 501-509 | ||||
| Date: | 2019 | ||||
| Institutions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie | ||||
| Identification Number: |
| ||||
| Keywords: | PREDICTIVE IMAGING BIOMARKER; ADC HISTOGRAM ANALYSIS; CEREBRAL BLOOD-VOLUME; RECURRENT GLIOBLASTOMA; PLUS IRINOTECAN; TEMOZOLOMIDE; PROGRESSION; EFFICACY; Bevacizumab; Irinotecan; Newly diagnosed MGMT-non-methylated glioblastoma; MRI; Predictive and prognostic implications | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 48280 |
Abstract
Purpose The phase II GLARIUS trial assigned patients with newly diagnosed, O-6-methylguanine-DNA methyltransferase promoter non-methylated glioblastoma to experimental bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ). To identify subpopulations with a particularly favorable course, we assessed the prognostic potential of magnetic resonance imaging (MRI) markers before treatment ...

Abstract
Purpose The phase II GLARIUS trial assigned patients with newly diagnosed, O-6-methylguanine-DNA methyltransferase promoter non-methylated glioblastoma to experimental bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ). To identify subpopulations with a particularly favorable course, we assessed the prognostic potential of magnetic resonance imaging (MRI) markers before treatment onset. Methods MRIs at baseline (before treatment onset) were analyzed for T1-hyperintense and diffusion-restricted lesions; as well as the presence of both hyperintense and diffusion-restricted (double positive) lesions. The MRI findings were correlated with overall and progression-free survival. Results MRI scans were evaluable in 71% of the GLARIUS modified intention-to-treat population (n = 121 of 170; 88 patients in the BEV/IRI arm, and 33 patients in the TMZ control arm). Diffusion-restricted and T1 hyperintense lesions were present in 60% and 65% of patients in BEV/IRI arm, while 57% and 63% were found in the TMZ arm, respectively. Double positive lesions were found in 37% of BEV/IRI patients and in 39% of TMZ patients. Neither the presence of T1-hyperintense, diffusion-restricted lesions, nor double positive lesions were associated with improved survival. Conclusions Baseline T1-hyperintense and diffusion-restricted lesions are not suitable to predict progression-free or overall survival of patients treated with bevacizumab/irinotecan or temozolomide.
Metadata last modified: 03 Sep 2021 09:47
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