Item type: | Article | ||||
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Journal or Publication Title: | Journal of Neuro-Oncology | ||||
Publisher: | Springer | ||||
Place of Publication: | NEW YORK | ||||
Volume: | 144 | ||||
Number of Issue or Book Chapter: | 3 | ||||
Page Range: | pp. 501-509 | ||||
Date: | 2019 | ||||
Institutions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie | ||||
Identification Number: |
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Keywords: | PREDICTIVE IMAGING BIOMARKER; ADC HISTOGRAM ANALYSIS; CEREBRAL BLOOD-VOLUME; RECURRENT GLIOBLASTOMA; PLUS IRINOTECAN; TEMOZOLOMIDE; PROGRESSION; EFFICACY; Bevacizumab; Irinotecan; Newly diagnosed MGMT-non-methylated glioblastoma; MRI; Predictive and prognostic implications | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 48280 |
Abstract
Purpose The phase II GLARIUS trial assigned patients with newly diagnosed, O-6-methylguanine-DNA methyltransferase promoter non-methylated glioblastoma to experimental bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ). To identify subpopulations with a particularly favorable course, we assessed the prognostic potential of magnetic resonance imaging (MRI) markers before treatment ...
Abstract
Purpose The phase II GLARIUS trial assigned patients with newly diagnosed, O-6-methylguanine-DNA methyltransferase promoter non-methylated glioblastoma to experimental bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ). To identify subpopulations with a particularly favorable course, we assessed the prognostic potential of magnetic resonance imaging (MRI) markers before treatment onset. Methods MRIs at baseline (before treatment onset) were analyzed for T1-hyperintense and diffusion-restricted lesions; as well as the presence of both hyperintense and diffusion-restricted (double positive) lesions. The MRI findings were correlated with overall and progression-free survival. Results MRI scans were evaluable in 71% of the GLARIUS modified intention-to-treat population (n = 121 of 170; 88 patients in the BEV/IRI arm, and 33 patients in the TMZ control arm). Diffusion-restricted and T1 hyperintense lesions were present in 60% and 65% of patients in BEV/IRI arm, while 57% and 63% were found in the TMZ arm, respectively. Double positive lesions were found in 37% of BEV/IRI patients and in 39% of TMZ patients. Neither the presence of T1-hyperintense, diffusion-restricted lesions, nor double positive lesions were associated with improved survival. Conclusions Baseline T1-hyperintense and diffusion-restricted lesions are not suitable to predict progression-free or overall survival of patients treated with bevacizumab/irinotecan or temozolomide.
Metadata last modified: 03 Sep 2021 09:47