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Inward-facing conformation of a multidrug resistance MATE family transporter

Zakrzewska, Sandra ; Mehdipour, Ahmad Reza ; Malviya, Viveka Nand ; Nonaka, Tsuyoshi ; Koepke, Juergen ; Muenke, Cornelia ; Hausner, Winfried ; Hummer, Gerhard ; Safarian, Schara ; Michel, Hartmut



Abstract

Multidrug and toxic compound extrusion (MATE) transporters mediate excretion of xenobiotics and toxic metabolites, thereby conferring multidrug resistance in bacterial pathogens and cancer cells. Structural information on the alternate conformational states and knowledge of the detailed mechanism of MATE transport are of great importance for drug development. However, the structures of MATE ...

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