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Role of HSP70 protein in human periodontal ligament cell function and physiology

Wolf, Michael ; Marciniak, Jana ; Lossdörfer, Stefan ; Kirschneck, Christian ; Brauner, Isabel ; Götz, Werner ; Jäger, Andreas


Objective: Heat pre-treatment of mechanically loaded human periodontal ligament cells (hPDL) dampens the inflammatory cellular response, as evidenced by a reduced expression of pro-inflammatory cytokines, inhibition of monocyte adhesion and osteoclastic differentiation. These findings imply heat shock proteins (HSP) as cell protective molecules acting in the PDL that are up-regulated upon ...


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