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Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy

Velicki, Lazar ; Jakovljevic, Djordje G. ; Preveden, Andrej ; Golubovic, Miodrag ; Bjelobrk, Marija ; Ilic, Aleksandra ; Stojsic, Snezana ; Barlocco, Fausto ; Tafelmeier, Maria ; Okwose, Nduka ; Tesic, Milorad ; Brennan, Paul ; Popovic, Dejana ; Ristic, Arsen ; MacGowan, Guy A. ; Filipovic, Nenad ; Maier, Lars S. ; Olivotto, Iacopo


BackgroundHypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. HCM is a recognized genetic disorder most often caused by mutations involving myosin-binding protein C (MYBPC3) and beta -myosin heavy chain (MYH7) which are responsible for approximately three-quarters of the identified mutations.MethodsAs a part of the ...


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