Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | Molecular Metabolism | ||||
Verlag: | ELSEVIER | ||||
Ort der Veröffentlichung: | AMSTERDAM | ||||
Band: | 42 | ||||
Seitenbereich: | S. 101076 | ||||
Datum: | 2020 | ||||
Institutionen: | Medizin > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | SEROTONIN TRANSPORTER BINDING; CHAIN FATTY-ACIDS; D-2/3 RECEPTOR AVAILABILITY; BARIATRIC SURGERY; INSULIN SENSITIVITY; I-123-FP-CIT SPECT; WEIGHT-LOSS; MICROBIOTA; DOPAMINE; OBESITY; Obesity; Gutmicrobiota; Gut-brain axis; Metabolites | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 49454 |
Zusammenfassung
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. Metkods: We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) ...
Zusammenfassung
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. Metkods: We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral butyrate supplementation on (I-123-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin transporter (SERT) binding as well as stable isotope-determined insulin sensitivity at baseline and after 4 weeks in 24 male and female treatment-naive metabolic syndrome subjects. Plasma metabolites and fecal microbiota were also determined at these time points. Results: We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression. Conclusions: Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated. NTR registration: 4488. (c) 2020 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Metadaten zuletzt geändert: 11 Okt 2021 12:35