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Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo

Broeker, Katharina A. E. ; Fuchs, Michaela A. A. ; Schrankl, Julia ; Kurt, Birgül ; Nolan, Karen A. ; Wenger, Roland H. ; Kramann, Rafael ; Wagner, Charlotte ; Kurtz, Armin



Abstract

Genetic induction of hypoxia signaling by deletion of the von Hippel-Lindau (Vhl) protein in mesenchymal PDGFR-beta(+) cells leads to abundant HIF-2 dependent erythropoietin (EPO) expression in the cortex and outer medulla of the kidney. This rather unique feature of kidney PDGFR-beta(+) cells promote questions about their special characteristics and general functional response to hypoxia. To ...

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