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Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure

Eiringhaus, Jörg ; Wünsche, Christoph M. ; Tirilomis, Petros ; Herting, Jonas ; Bork, Nadja ; Nikolaev, Viacheslav O. ; Hasenfuss, Gerd ; Sossalla, Samuel ; Fischer, Thomas H.



Abstract

Aims Inhibition of neprilysin and angiotensin II receptor by sacubitril/valsartan (Val) (LCZ696) reduces mortality in heart failure (HF) patients compared with sole inhibition of renin-angiotensin system. Beneficial effects of increased natriuretic peptide levels upon neprilysin inhibition have been proposed, whereas direct effects of sacubitrilat (Sac) (LBQ657) on myocardial Ca(2+)cycling remain ...

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